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Multi-organ impairment in Long Covid



Today is the National Day of Reflection and marks 2 years since the first day of lockdown in the UK. For many of us this came woefully too late. We were already infected.

Currently the UK government is again letting Covid variants rip through our society meaning that apart from DEATH (1-2%), the other outcome will be DISABILITY (up to 30%). It is so shortsighted of them to think that they are "saving the economy" or "returning to normal". 30,000 people a day infected with a deadly, disabling virus IS NOT NORMAL. They will have to be pay out thousands of pounds out for doctors, nurses, paramedics, teachers etc who will be forced to claim Universal Credit and PIP as they have been disabled, cognitively and/or physically, by exposure to Covid-19 and can no longer work. Not to mention the thousands it costs to train up the replacement staff that will be needed. It honestly makes me sick to my very core. Here is the EVIDENCE that they are choosing to ignore.This is a preprint from the COVERSCAN study. Please see my previous posts on their work so far.


"Multi-organ impairment associated with Long COVID is a significant burden to individuals, populations and health systems, presenting challenges for diagnosis and care provision.

Standardised assessment across multiple organs over time is lacking, particularly in non-hospitalised individuals.


What they wanted to find out

To determine the prevalence of organ impairment in Long COVID patients at 6 and at 12 months after initial symptoms and to explore links to clinical presentation.


How they did it

This was a prospective, longitudinal study in individuals following recovery from acute COVID-19. We assessed symptoms, health status, and multi-organ tissue characterisation and function, using consensus definitions for single and multi-organ impairment. Physiological and biochemical investigations were performed at baseline on all individuals and those with organ impairment were reassessed, including multi-organ MRI, 6 months later.

Participants were recruited from two non-acute settings - Oxford and London.

536 individuals:

  • mean 45 years

  • 73% female

  • 89% white

  • 32% healthcare workers

  • 13% acute COVID-19 hospitalisation

The participants completed baseline assessment at around 6 months post-COVID-19).


What they found

At "baseline" (6 months post acute Covid-19 infection)

  • OVER HALF had single organ impairment (59%)

  • 23% had multi-organ impairment

  • 331 (62%) had organ impairment or incidental findings

  • Median number of symptoms was 10

  • Cognitive dysfunction in 50%

  • Extreme breathlessness in 36%

  • Poor health related quality of life 55% (over half) and was associated with organ impairment, being younger and female

  • Fibro-inflammation in the heart 9% (that's almost 1 in 10)

  • Inflammation of the pancreas 9%

  • Inflammation of the kidney 15%

  • Inflammation of the liver 11%

  • Increased volume in the liver 7%, spleen 8% and kidney 9%

  • Decreased lung capacity 2 %

  • Fatty liver 25% fatty pancreas 15%


At 12 months:

  • Single organ impairment persisted in 59%

  • Multi-organ impairment persisted in 27% (actually increased at 1 year)


Their conclusion

Organ impairment was present in 59% of individuals at 6 months post-COVID-19, persisting in 59% of those followed up at 1 year, with implications for symptoms, quality of life and longer-term health, signalling need for prevention and integrated care of Long COVID."


We have to remember that this is a study just looking at specialised scans of the heart and other internal organs. It does not include those who then die of a heart attack or a stroke or a pulmonary embolus as a delayed outcome of their acute Covid-19 infection. Nor does it include those disabled by cognitive dysfunction or Postural Orthostatic Tachycardia Syndrome etc.


Reference

Trial Registration: ClinicalTrials.gov NCT04369807

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